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Milestones in human genome mapping and sequencing are among the topics covered in special fall issues of Nature and Science.
Nature
The Genome Directory, a 379-page supplement to the September 28 issue of Nature, features a compendium by Craig Venter [The Institute for Genomic Research (TIGR)] of 88,000 unique ESTs from cDNA sequences expressed in 37 human tissues at various developmental stages.
The issue also features a description of the latest G?n?thon YAC contig map of the human genome by Daniel Cohen and Ilya Chumakov (CEPH) and colleagues. The map covers 75% of the human genome in 225 contigs having an average size of 10 Mb.
Detailed physical maps of four human chromosomes are also presented.
Chromosomes 3 and 12. More-detailed, second-generation YAC contig maps based on the original G?n?thon YAC physical map. The chromosome 3 map by Robert Gemmill and Harry Drabkin (Eleanor Roosevelt Institute) and colleagues covers 80% of the chromosome in 24 contigs and incorporates physical and genetic map data. Raju Kucherlapati (Albert Einstein College of Medicine) and his collaborators describe a map covering about 75% of human chromosome 12 in 13 contigs and incorporating genetic, physical, and cytogenetic map data.
Chromosome 22. High-density YAC contig map by Ian Dunham (Sanger Centre) and colleagues representing the practical limits of currently available YAC resources and comprising available physical and genetic data.
Chromosome 16. Map incorporating a low-resolution map of mega-YACs and a high-resolution sequence-ready map of cosmid contigs and mini-YACs. The map, by Robert Moyzis and Norman Doggett (Los Alamos National Laboratory) and associates, includes physical, genetic, and cytogenetic data and provides almost complete coverage of the chromosome 16 euchromatic arms. |
| Author: Aaron Hall |
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